Our skin conditions deteriorate over a slew of reasons – prolonged exposure to UV radiation under the sun, smoking tobacco, regular consumption of alcohol, and even our dietary habits. Exacerbating the natural aging process, these factors further impair our critical bodily functions such as DNA repairing, hormonal imbalances, and cellular damages.
Our lifestyles, habits, and aging degenerate the epidermis, which forms the first outermost barrier of our skin, and the dermis, which is the thickest layer of our skin that is composed mostly of fibrous and elastic connective tissues that lend our skin its tensile strength and elasticity. Sunekos has developed solutions that help repair aging tissues, by stimulating the reproduction of fibroblasts to restore our skin’s epidermis and dermis back to their youthful characteristics.
HY6AA: Combines Special AAs to Produce Collagen and Elastin
The patented HY6AA formula feeds the Extracellular Matrix (ECM) its structural physiological components to help restore homeostasis and fix them. Globally, HY6AA is known to be the only existing formula that is clinically proven, and has been patented in 9 countries, including Singapore, USA, Europe, Canada, and Australia.
The methodology applied to successfully maximise elastin and collagen production was rooted in specific Amino Acids (AA) formulas intended to target energy metabolism and protein synthesis modulation for different clinical indications, such as curing metabolic diseases and disorders like sarcopenia, which is the degenerative loss of skeletal muscle mass due to aging and immobility.
Sunekos’ R&D has ventured beyond conventions to regenerate ECM by providing a specific and precise mix of all its necessary constituents to achieve a perfectly physiological process. Typically, medical research applies a non-physiological stimulation methodology which is generally “non-specific”, stimulating fibroblasts to improve proteins in the dermis, but a side-effect is that this technique leads to stress and exhaustion of the fibroblast.
Thus, Sunekos Injectable line is programmed to adopt a ‘specific’ and ‘targeted’ approach to achieve dermal biogenesis.
What AAs do for the skin?
Out of the 500 naturally-occurring known AAs, only 20 appear in our genetic code. AAs, an organic compounds made up of carbon (C), hydrogen (H), oxygen (O), and nitrogen (H) elements, join to form short polymer chains known as peptides, while the longer chains are called polypeptides or proteins. Our genetic DNA information is transferred to a messenger RNA (mRNA) template which interacts with ribosomes that read AAs in specific sequences. Then, the transfer RNA (tRNA) assembles the AAs to form protein. Basically, AAs are building blocks of proteins.
Although the fibroblasts can be stimulated using only Hyaluronic Acid (HA) singularly, it is still highly essential to combine this with an optimal quantity of AAs to adequately induce mRNA expression for production of structural proteins. This should ensure proper physiological and specific stimulation of the ECM fibroblast to maximize biorevitalization.
In 2017, a published research conducted in Italy verified that the simultaneous stimulation of collagen and elastin is the scientific community’s first-ever confirmation based on the hypotheses tested in-vitro in a clinical setting.
The patented ‘golden ratio’ balanced formula has proven to have demonstrated a simultaneous and ordered activation of both collagen and elastin, capable of combating elastosis.
Rejuvenating Collagen and Elastin: How The Regeneration Works
Aging degenerates our skin because this natural process accelerates the loss of ECM homeostatsis, due to a reduction in fibroblast activity and quantity, and hydration losses. Fibroblast degradation equates to having less collagen and elastin. The ECM is composed of water, structural proteins, specialized proteins, and proteoglycans.
However, the main components are elastin, the 28 types of collagens categorized under structural proteins, and hyaluronan which is linked with proteoglycan in the ECM.
Amongst the 28 types of collagen, the most common Type I constitutes 80-90% of the substance. Type IV is the predominant component in the basement membranes (BM), also simply known as deep dermis, which is a connective tissue anchoring the dermis to its underlying structures. Not only is the synthesis of collagen diminished over time, collagen fibers would also fragmentate and the ensuing disorientation increases dermal rigidity. Such is the natural aging process that causes our skin to gradually lose its tensile strength.
Only certain AAs with a specific combination of each can re-activate fibroblast growth. The AA sequence mainly consists of glycine, proline, hydroxyproline, hydroxylysine, and alanine. The following 3 AA types represent almost 70% of the collagen structure – glycine, alanine, proline (both free and hydroxylated). Thus, these 3 AA types combine to form the possible sequences of collagen. In fact, lacking in any of these key structural elements lead to an incomplete structure of the collagen chains. A precise amount in percentage composition of the AA mix is integral to generating the correct protein synthesis.
Adding small mixtures of AAs to HA can enhance the overall biological performance, such as wound healing. Achieving the optimal golden ratio guarantees an adequate and balanced response to gene expression and production of fibroblast, collagen, and elastin.
HA of more than 1,000,000 Dalton, which is adopted by Sunekos Body injectable, acts as an antioxidant that protects fibroblasts and structural elements of the dermis as a free-radical “scavenger”. This means that it helps protect cells from damage caused by free radicals which are unstable molecules produced during normal cell metabolism.
Understanding Why the 6 AAs ‘Golden Ratio’ Matters
Studies have reinforced the hypothesis that large amounts of Glycine, Lysine, and Proline, are needed for collagen synthesis. After L-Lysine induces the activation of specific hydroxylases, the hydroxylation of glycine and proline initiates inter- and intra-molecular bond formations to give collagen its viscoelastic properties.
A published research on AA concentration has substantiated the linear relationship between Type IV collagen protein production and composition of AAs present. While low AA concentrations translate into low stimulation of collagen IV, inadequate AA amounts carry the risk of not even stimulating collagen synthesis.
Type IV collagen forms the ‘backbone’ of the ECM basement membrane and functions as a cellular barrier between tissue components.
Alanine and Valine are essential to the promotion of elastin. Particularly, an elastin AA sequence consists of a precise mix of Glycine, Proline, Valine, and Alanine. Individual elastin molecules are held together by cross-linkages to form an elastin fiber, possessing sufficient tensile strength to withstand stretches, and restoring its original structure in post-stretch phase.
In other words, its elasticity mimics a youthful skin that contains enough “cushion” with little evidence of the sagging skin which possesses comparably less elastin. The last of 6 AAs, Leucine, is an essential amino acid that promotes protein biosynthesis. As small changes to its composition in an AA mixture activates a different protein synthesis modulation, the HY6AA formula adopts a precise leucine concentration to achieve a targeted stimulation.
New Anti-Aging Paradigm
Clinical efficacy evaluation of Sunekos injectables on consenting subjects of ages between 48-65 years old proved statistically significant improvement of wrinkle severity and cheek volume, and reduction of crow’s feet. These phenomena were observed within 3 months of the first injection.
The study also reported the hydration of deep skin layers at 0.5mm of depth within 30 days of the first injection. Sunekos’ treatment protocol only requires 1 injection per week for 4 weeks, targeted at ECM stimulation to restore our skin’s tensional integrity, or also known as “Tensegrity”.
With the robust backing of scientific evidence and intensive clinical trials, Sunekos’ HY6AA patented formula promises to rebuild damaged skin to help us look young again.